氧感應通路與腫瘤細胞對放療和化療的耐藥作用相關。隨著腫瘤的生長，腫瘤細胞可以感應到環境中氧氣的緊張并重新編程與癌細胞生存和治療抵抗密切相關的關鍵途徑。這種重新編程的其中一個例子是通過上調缺氧誘導因子α（HIF-alpha）和激活HIF信號下游通路。

張博士的實驗室主要致力于研究氧感應通路，以及它們如何促進腫瘤的發展以及治療耐藥。張博士的實驗室正在實施新的基因組和蛋白質組學方法，以確定乳腺癌和腎癌中氧感應信號的重要新治療靶點。在本次云講堂直播間，張博士將為我們帶來圍繞氧感應通路而發現的治療新靶點，包括乳腺癌新靶點BBOX1以及腎癌新靶點ZHX2、SFMBT1、TBK1等。

09月10日晚19:00--20:00，張青教授將為我們帶來《乳腺癌和腎癌治療新靶點的發現和確證》，歡迎大家準時收看！

Hypoxia is associated with resistance towards radiation and chemotherapy. As tumors grow, they can sense the oxygen tension and reprogram critical pathways that are important for cancer cell survival and therapy resistance. One of examples is through upregulation of hypoxia inducible factor alpha (HIF-α) and activation of HIF signaling downstream pathways. Dr. Zhang’s lab is mainlyinterested in studying the oxygen-sensing pathway and how they contribute tothe development of tumors as well as therapeutic resistance. Dr. Zhang’s lab is implementing novel genomic and proteomic approaches to identify important new therapeutic targets in oxygen sensing signaling in breast and kidney cancers. During this talk, Dr. Zhang will present on identifying BBOX1 as a new therapeutic target in breast cancer. In addition, Dr. Zhang will present on identifying a few new therapeutic targets in kidney cancer, including ZHX2,SFMBT1 and TBK1.