信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子(signal transducer and activator of transcription, STAT)是一大類(lèi)具有細(xì)胞質(zhì)內(nèi)信號(hào)轉(zhuǎn)導(dǎo)和細(xì)胞核內(nèi)轉(zhuǎn)錄激活雙重作用的蛋白，廣泛存在于哺乳動(dòng)物細(xì)胞中，介導(dǎo)多種細(xì)胞內(nèi)信號(hào)通路。

The signal transducer and activator of transcription (STAT) is a family of intracellular cytoplasmic transcription factors involved in many biological functions in mammalian signal transduction.

STAT3是一種在多種組織中表達(dá)的信號(hào)分子。STAT3參與細(xì)胞增殖、分化、凋亡和炎癥反應(yīng)等多種生物學(xué)過(guò)程。然而，STAT3在大多數(shù)人類(lèi)癌癥中變得過(guò)度激活，通常與不良的臨床預(yù)后有關(guān)。

Among them STAT3 is involved in cell proliferation,differentiation,apoptosis and inflammatory responses, and also STAT3-related signaling pathways are a barren over-activated in many types of cancer and are strongly associated with poor patient prognosis.

腫瘤微環(huán)境（TME）中腫瘤細(xì)胞內(nèi)STAT3過(guò)度激活會(huì)介導(dǎo)一系列細(xì)胞外信號(hào)，增強(qiáng)腫瘤微環(huán)境的免疫炎癥反應(yīng)，驅(qū)動(dòng)腫瘤細(xì)胞增殖、侵襲和轉(zhuǎn)移，同時(shí)強(qiáng)烈抗腫瘤免疫反應(yīng)并創(chuàng)造免疫抑制微環(huán)境。

Excessive activation of STAT3 within tumor cells and other cells in the tumor microenvironment (TME) mediates a series of extracellular signals that enhances the immune inflammatory response in a TME, driving tumor cell proliferation, invasion, and metastasis, while strongly suppressing the anti-tumor immune response and creating an immunosuppressive microenvironment.

研究表明，持續(xù)激活的STAT3對(duì)于多種癌癥是必不可少的，比如乳腺癌和結(jié)直腸癌，這使得STAT3成為理想的藥物靶點(diǎn)。

Studies have indicated that persistently activated STAT3 is indispensable for various cancers including breast cancer and coleractal cancer ,which makes it an ideal drug target.

美迪西可提供STAT3藥物發(fā)現(xiàn)、CMC研究（API+制劑）、藥效研究、PK研究、安全性評(píng)價(jià)等一站式研發(fā)服務(wù)。

Medicilon provides STAT3 drug discovery, CMC Research (API + formulation), pharmacodynamics research, PK study, safety evaluation and other services.

STAT3藥物靶點(diǎn)研發(fā)服務(wù)

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